Tadalafil |
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| CAS No. : | 171596-29-5 |  |
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| Formula: | C22H19N3O4 | ||||||
| M.Wt: | 389.4 | ||||||
| Synonyms: | Cialis,ICOS 351,Ic351,IC 351,IC-351 Metabolism | ||||||
| Target: | PDE | ||||||
| Pathway: | Store at -20°C | ||||||
| Storage: | A4327 | ||||||
| Solvent & Solubility | |||||||
| In Vitro | insoluble in H2O; insoluble in EtOH; ≥16.6 mg/mL in DMSO | ||||||
| Preparing Stock Solutions |
Mass | 1mg | 5mg | 10mg | |||
| Solvent | |||||||
| Concentration | |||||||
| 1 mM | 2.5681 mL | 12.8403 mL | 25.6805 mL | ||||
| 5 mM | 0.5136 mL | 2.5681 mL | 5.1361 mL | ||||
| 10 mM | 0.2568 mL | 1.2840 mL | 2.5681 mL | ||||
| Biological Activity | |||||||
| In Vitro | Cell Viability Assay | ||||||
| Cell Line: | human hepatocytes | ||||||
| Preparation method： | The solubility of this compound in DMSO is >16.6mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
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| Reacting conditions: | 1 pM | ||||||
| Applications: | Tadalafil (1 μM) increased CYP3A protein expression in human hepatocytes. | ||||||
| In Vivo | Animal experiment | ||||||
| Animal models: | Rat model with bilateral cavernous neurotomy (BCN)-induced penile damage and hypo-oxygenation, Mice with cavernous nerve resection |
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| Dosage form: | 2 mg/kg, daily for 3 months | ||||||
| Applications: | Tadalafil (2 mg/kg) almost completely restored penile oxygenation and abolished neurotomy induced increase and substantially rescued muscle/fiber ratio in penile sectionsin sham-operated rats. Tadalafil decreased the number of apoptotic cells and increased the phosphorylation of the 2 survival associated kinases Akt and extracellular signal-regulated kinase 1/2 in mice. |
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| Other notes: | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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